Beaten 3-0 by Bundesliga leaders Bayer Leverkusen at the weekend, Bayern set out to make amends in Rome as Joshua Kimmich flashed an early effort wide. Harry Kane could do no better after meeting a Thomas Müller cross, before Lazio began to threaten at the other end. Alessio Romagnoli headed straight at Manuel Neuer, while Luis Alberto fizzed a long-range strike narrowly wide. Leroy Sané and Gustav Isaksen exchanged shots from outside the area that failed to find the target as the first half ended all square.
Neuer made a crucial block to thwart Isaken soon after the restart. Jamal Musiala then directed a close-range strike from Noussair Mazraoui's teasing cross wide. Kane powered a header over as Bayern tried to steal a first-leg advantage, but they were left with it all to do when Upamecano was sent off for a 66th-minute lunge on Isaksen. Former Borussia Dortmund striker Immobile sent Neuer the wrong way from the resultant penalty to leave Bayern needing a win at the Allianz Arena on 5 March, if they're to reach the quarter-finals.
Match stats
Bayern lost a last-16 first leg for the first time since 2012, when they lost 1-0 in Basel before winning 7-0 at home.
Kane was stopped from scoring for only the ninth time in 28 competitive starts for Bayern.
Indeed, Bayern did not have a single shot on target.
Two-time Champions League winner Müller made his 147th appearance in the competition - an on-going record for a German player.
Bayern beat Lazio 6-2 on aggregate in the 2021/22 Champions League round of 16, winning 2-1 at home and 4-1 away in their only previous meetings with the Roman club.
The six-time Champions League winners have advanced beyond the last 16 in 12 of the last 14 seasons.
Champions League Round of 16, 1st leg Round of 16, 1st leg Stadio Olimpico, Rome
Full-time: Lazio 1-0 Bayern
Ciro Immobile's second-half penalty settles the first leg in Rome. Bayern were reduced to ten men following Dayot Upamecano's sending off but Thomas Tuchel's men are far from out of this tie and will fancy their chances of advancing after the teams' second-leg meeting at the Allianz Arena on 5 March.
Lazio sub Pedro wriggles his way through before sending a shot into the arms of Manuel Neuer.
90'
Kim's crucial block
The Bayern defender prevents Felipe Anderson's shot from finding a way through on Neuer's goal. A really important intervention from Kim there.
89'
Time added on
We'll have five extra minutes at the Stadio Olimpico.
85'
Kane free kick
The England international takes his time over the set-piece on the edge of the Lazio box but his effort is blocked.
82'
Double swap
Bayern introduce Mathys Tel and Eric Maxim Choupo-Moting for the closing stages at the Stadio Olimpico. Former Eintracht Frankfurt man Daichi Kamada is on for Lazio.
Bayern have been rocked by that double blow of going behind and losing Upamecano to a red card. Thomas Tuchel is forced into a change with Matthijs de Ligt on for Leon Goretzka.
Dayot Upamecano has been sent off for a lunge on Gustav Isaksen inside the Lazio area. It's a penalty for the hosts while a furious Upamecano has been ordered off.
Gustav Isaksen takes advantage of some great work by Luis Alberto and the Dane suddenly has a great chance to put Lazio ahead. Manuel Neuer stands firm to make a block and that's kept Bayern on terms.
46'
Off we go again
The second half is underway at the Stadio Olimpico.
45'
+ 1
Half-time: Lazio 0-0 Bayern
A decent first-half from the Bundesliga side with Leroy Sané and Jamal Musiala having the game's best chances for the visitors. Thomas Tuchel might demand a little more from his team in terms of attacking threat after the break.
45'
Additional time
There will be one minute of time added on in Rome.
40'
Bayern working well
This is a lovely build-up from the visitors, with some slick, quick passing. Goretzka and Sané combine before working the ball in for Musiala, who swipes over the top.
36'
Action at both ends
Müller, Musiala and Kane try to conjure something but it's all a bit hurried and the move eventually breaks down. At the other end, Isaksen cuts inside and whacks a shot over the crossbar.
Shot count on the rise
Sané's free-kick - which was a whisker away from going in - brings Bayern's chance count up to six. Lazio have had three efforts on goal in this intriguing first-leg.
Bayern work a training-ground free-kick on the edge of the Lazio area and it results in Sané shooting narrowly wide.
29'
No go Upamecano
It's Upamecano's turn this time to shoot and the defender's effort is never troubling Ivan Provedel in the Lazio goal.
27'
Italians defending well
Maurizio Sarri has his team well set up here and the Italians' compact defensive set-up is frustrating Bayern in large parts.
Decent battle
This has been an entertaining encounter thus far. Bayern are bossing in terms of the possession stakes, the Bavarian giants with 54 per cent of the ball thus far.
Luis Alberto smashes a shot at the target from distance and the power takes the ball fizzing inches off target. Neuer was relieved to see that one fly away.
18'
Lazio chance
The hosts have been quiet in attack thus far tonight but win a corner which Luis Alberto takes. Romagnoli meets the set-piece with a header but Neuer saves with relative ease.
14'
Move breaks down
Kane is very close to picking out Müller inside the area but the ball is played just too far ahead of the Bayern No. 25.
10'
Musiala next up
Jamal Musiala dallies a little too long over the ball inside the Lazio box and the attacker's shot is blocked out.
7'
Kane menacing
Kimmich finds Müller who hooks a pass in for Harry Kane. The English striker knocks a bouncing ball over the top. That was a decent chance for the Bundesliga side.
4'
Visitors with the ball
Thomas Tuchel's men are pushing Lazio's defence back with some dominant possession play. The hosts look to be set up to soak up the Bayern pressure while waiting for chances to break.
2'
Solid start for Bayern
Sané gets into the Lazio box and is able to cut back for Kimmich, who shoots just off target.
1'
Away we go!
The action is underway at the Stadio Olimpico!
Teams out
Both sets of teams are lining up in Rome and all that's left ahead of kick-off is the Champions League anthem.
Bayern seek advantage
The record Bundesliga champions are keen to take a positive result here tonight to bring back to Munich on 5 March. The pre-game stats tell a good tale for Thomas Tuchel's men, who haven't lost a Round of 16 first leg in the last 11 seasons.
It's not just Lazio's Immobile who has past Bundesliga experience. Midfielder Matteo Guendouzi spent the 2020/21 season on loan at Hertha Berlin while Daichi Kamada is a former DFB Cup and UEFA Europa League winner with Eintracht Frankfurt.
Former Borussia Dortmund forward Ciro Immobile - who scored three times in 24 Bundesliga games in 2014/15 - netted his 200th goal in Serie A last weekend while he boasts 12 goals in 21 appearances in the Champions League. The 33-year-old will need to be closely watched by the Bayern rearguard this evening.
Bayern coach Thomas Tuchel reverts back to a four-man defence and makes three personnel changes to the team that began Saturday's loss against Bayer Leverkusen. Raphaël Guerreiro, Joshua Kimmich and Thomas Müller all come in while Eric Dier, Sacha Boey, and Aleksandar Pavlović drop to the bench. Recent signing Bryan Zaragoza is also among the substitutes for the visitors this evening.
The hosts make just one change to the side that triumphed 3-1 against Cagliari at the weekend, with Uruguayan midfielder Matías Vecino in for Danilo Cataldi. Club captain and Lazio's top scorer Ciro Immobile leads the home attack.
Bayern starting XI
Neuer (c) - Mazraoui, Upamecano, Kim, Guerreiro - Kimmich, Goretzka - Sané, Müller, Musiala - Kane
Bayern subs
Ulreich, Schmitt, De Ligt, Choupo-Moting, Dier, Zaragoza, Boey, Tel, Pavlović
Lazio starting XI
Provedal - Marušić, Gila, Romagnoli, Hysaj, - Guendouzi, Vecino, Alberto - Isaksen, Immobile (c), Anderson
Lazio subs
Sepe, Magro, Patric, Kamada, Pedro Rodríguez, Casale, Castellanos, Lazzari, Cataldi
Tuchel on Lazio challenge
Bayern's official website has been delivering more updates from the team's official press conference. This time it's Thomas Tuchel who has been speaking. "As ever with [Lazio coach] Maurizio Sarri [teams], they keep things tight and are tough to beat. I think it'll be an emotional game with the fans. We need to be prepared."
New Bayern defender Eric Dier has featured in four Bundesliga games for the Bavarian giants since completing his move from Tottenham Hotspur in January. The England international - who once played in a Champions League final for his former side and who boasts 30 Champions League appearances - is in line for a first game in the competition with the record German champions.
Previous meeting
These two teams met at the same stage of the competition three years ago, with Bayern prevailing 6-2 on aggregate to advance to the quarter-finals. Robert Lewandowski (2), Jamal Musiala, Leroy Sané, Eric Maxim Choupo-Moting and a Francesco Acerbi o.g. accounted for the Bayern goals across the two legs.
Neuer upbeat
Bayern captain Manuel Neuer has been speaking at his team's press conference in Rome and his words have been captured by the club's official website: "After a bad experience like Leverkusen it's nice to play again as quickly as possible," the legendary goalkeeper explained. "We have to remember the success we've had in the Champions League this season and take that with us," he added.
Bayern's goal-king Harry Kane is joint-second on the Champions League list of goal involvements this season with seven (four goals, three assists). England's record goalscorer is the Bundesliga's leading marksman with an incredible 24 top-flight goals this term while he has also weighed in with five assists.
Early team news
The visitors might be expected to line up thusly on Wednesday: Neuer (c) - Mazraoui, Upamecano, Kim, Guerreiro - Kimmich, Goretzka - Müller, Musiala, Sané - Kane. The Bayern absentee list is lengthy and reads: Aséko (ankle), Buchmann (thigh), Coman (knee), Davies (knee), Gnabry (thigh), Laimer (calf), Peretz (knee), Sarr (knee). New signing Bryan Zaragoza has recovered from illness and is in contention to make his Bayern debut.
Bounce-back-ability
Bayern stormed through the group stages to set up this knockout tie with Maurizio Sarri's Lazio. Yet last weekend's setback against domestic title rivals Bayer Leverkusen will have raised some questions about morale at the Bavarian giants going into Wednesday's first leg. Can Thomas Tuchel lift his team for what is set to be a huge occasion at the Stadio Olimpico?